Alcohol dependence is a widespread issue affecting millions of individuals globally. Thankfully, medical science has developed various treatments to help those struggling with alcohol addiction. Acamprosate, a medication often used in these treatments, has been instrumental in helping individuals on their journey to sobriety. However, like any medication, it comes with potential side effects that must be considered. In this comprehensive guide, we will delve into the world of Acamprosate side effects, providing you with the essential information you need.

Acamprosate side effects

Acamprosate Side Effects: An Overview

Acamprosate, commonly known by its brand name Campral, is a medication prescribed to individuals who have successfully ceased alcohol consumption. Its primary purpose is to support long-term abstinence from alcohol by reducing cravings. While it is a beneficial drug, it is crucial to be aware of the possible side effects, which can vary in intensity from person to person.

Acamprosate side effects
Acamprosate side effects

Headache and Nausea

One of the most frequently reported side effects of Acamprosate is headaches and nausea. Some individuals may experience mild discomfort, while others might find these side effects more pronounced. Staying well-hydrated and taking the medication with food can help alleviate these symptoms.

Digestive Issues

Digestive problems, including diarrhea and abdominal discomfort, can occur when taking Acamprosate. If these issues persist or become severe, it is essential to consult with your healthcare provider.

Allergic Reactions

In rare cases, individuals may develop allergic reactions to Acamprosate, which can manifest as hives, itching, swelling of the face or throat, and difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

Mood Changes

Some users of Acamprosate have reported mood changes, including depression or anxiety. It’s crucial to monitor your emotional well-being while taking this medication and inform your healthcare provider of any concerning changes.

Acamprosate Side Effects in Detail

Now, let’s dive deeper into the potential side effects of Acamprosate:


Difficulty sleeping, or insomnia, is a side effect that can affect some individuals. Establishing a healthy sleep routine and discussing this issue with your doctor can help manage insomnia.

Muscle Weakness

Muscle weakness is another less common side effect. If you notice a significant loss of muscle strength while taking Acamprosate, consult your healthcare provider.

Loss of Appetite

A decreased appetite can occur in some individuals. Ensure you maintain a balanced diet despite any appetite changes.


Dizziness is a relatively common side effect. To prevent accidents, avoid activities that require alertness if you experience dizziness.


Excessive sweating, especially at night, can be bothersome for some users. Ensure proper hydration to manage this side effect.

Weight Changes

Acamprosate may lead to weight gain or loss in some cases. It’s essential to monitor your weight and discuss any significant changes with your healthcare provider.

Skin Reactions

Skin reactions, such as itching or rash, are rare but possible. Seek medical advice if you experience these symptoms.

FAQs About Acamprosate Side Effects

Can I drink alcohol while taking Acamprosate?

No, alcohol consumption while on Acamprosate is discouraged, as it may reduce the effectiveness of the medication and increase the risk of side effects.

How long do Acamprosate side effects typically last?

Side effects vary from person to person, but they often diminish within the first few weeks of treatment as the body adjusts to the medication.

Are there any serious side effects I should watch out for?

While rare, allergic reactions can be severe. If you experience hives, swelling, or difficulty breathing, seek immediate medical attention.

Can Acamprosate cause addiction?

Acamprosate itself is not addictive, and it does not produce a high. It is a medication designed to support recovery from alcohol addiction.

Is it safe to take Acamprosate during pregnancy?

It is essential to consult with a healthcare provider if you are pregnant or planning to become pregnant while taking Acamprosate. The potential risks and benefits should be discussed thoroughly.

Can Acamprosate be taken with other medications?

Discuss any other medications or supplements you are taking with your healthcare provider to ensure there are no potential interactions.


In the journey toward sobriety, Acamprosate can be a valuable tool, helping individuals reduce alcohol cravings and maintain abstinence. While it offers significant benefits, it’s essential to be aware of the potential side effects and consult with a healthcare provider if any concerns arise. By understanding Acamprosate side effects and staying informed, individuals can make informed decisions about their treatment options.

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